JCI Insight

Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. JCI Insight. 2019 May 16;4(10):e127456. doi: 10.1172/jci.insight.127456. eCollection 2019 May 16. PMID: 31092735

In a prospective study of patients with biopsy-confirmed AIN, the authors show that TNF-α and IL-9 are independently associated with AIN diagnosis and severity


Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Nephrol Dial Transplant. 2022 Oct 19;37(11):2214-2222. doi: 10.1093/ndt/gfab346. PMID: 34865148 PMCID: PMC9755995

Using machine learning feature selection technique called LASSO, the authors create an algorithm for diagnosis of biopsy-proven AIN using clinically available blood and urine tests.


Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians. Moledina DG, Parikh CR. Nephron. 2019;143(3):211-216. doi: 10.1159/000501207. Epub 2019 Jun 14. PMID: 31203275 PMCID: PMC6821567

The authors describe methods of differentiating Acute Interstitial Nephritis from Acute Tubular Injury using novel biomarkers

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